Antitubercular drugs: advances in nitrogen containing heterocyclic compounds and some other derivatives

Mohammad Asif

Abstract


Tuberculosis (TB) caused by Mycobacterium tuberculosis is an infectious disease. Control of TB is complicated by difficulties in the long-course chemotherapy treatment, the inability to eliminate latent microbes, and the increasing emergence of Multidrug Resistant (MDR) strains of M. tuberculosis. New anti-TB drugs are urgently needed, including developments of short-term treatments to minimize the emergence of drug resistance and new drugs to treat multidrug resistant tuberculosis and to eliminate the latent microbes. Many new structural anti-TB agents exhibited promising activities against susceptible and resistant strains of M. tuberculosis. The diarylquinoline with superior anti-tuberculotic activity and encouraging results of nitroimidazopyrans and oxazolidinones have generated considerable excitement.


Keywords


Tuberculosis; drug resistance; drug development; mycobacterial cell wall

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References


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DOI: http://dx.doi.org/10.14805/jphchem.2014.art15

DOI (PDF): http://dx.doi.org/10.14805/jphchem.2014.gal16

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