Effect of viscosity of hydrophilic coating polymer on lag time of atenolol pulsatile press coated tablets

Rajesh A Keraliya, Madhabhai M Patel


A method for the development of press coated tablet of atenolol for pulsatile delivery was investigated for chronotherapy of hypertension. Effect of viscosity of Hydroxypropylcellulose (HPC) on pulsatile release of atenlol was studied by press coating atenolol core tablet using different viscosity grade HPC and varying coat weight. L-HPC, M-HPC and H-HPC viscosity garde with 75, 100 and 150 mg coat weight were press coated over atenolol core tablets to delay release of atenolol. The batches, HP1-HP9, exhibited an increase in lag time in response to increase in viscosity and coat weight. Two of the batches HP5 and HP7 have shown a burst release of atenolol after 6.5 and 6.0 h lag time respectively, which is suitable for pulsatile drug delivery of atenolol for chronotherapy of hypertension.


Atenolol; chronotherapy; pulsatile release; press coating; hydroxypropylcellulose; hypertension

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DOI: http://dx.doi.org/10.14805/jphchem.2014.art2

DOI (PDF): http://dx.doi.org/10.14805/jphchem.2014.gal12


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