X-ray crystal structure of N'-[(1E)-1-(2,4-dihydroxyphenyl)-ethylidene]pyridine-4-carbohydrazide


  • Venkatesan Jayaprakash Birla Institute of Technology http://orcid.org/0000-0002-9724-4153
  • Ajay Kumar Timiri Birla Institute of Technology
  • Viswanathan Vijayan University of Madras
  • Barij Nayan Sinha Birla Institute of Technology
  • Velmurugan Devadasan University of Madras




Schiff’s base, Isonicotinyl hydrazide, X-ray crystallography


Schiff’s base of isonicotinyl hydrazide with 2’,4’-dihydroxy acetophenone (INH-RA) has been designed and synthesized as a part of library enumeration targeting the NS2B-NS3 protease of Dengue virus. Slow evaporation from methanol results in the formation of monoclinic crystals C2/c space group with eight molecules in the unit cell (a=20.0165(3) Å, b=7.7594(10) Å, c=19.4809(3) Å, α=90 °, β=111.368(1) °, γ=90 ° and Z=8).Three dimensional X-ray crystallographic structure of the compound has been determined and refined using SHELXS-97 and SHELXL-2014, respectively to a final R-value of 4.64%

Author Biographies

Venkatesan Jayaprakash, Birla Institute of Technology

Department of Pharmaceutical Sciences & Technology

Associate Professor

Ajay Kumar Timiri, Birla Institute of Technology

Department of Pharmaceutical Sciences & Technology

Research Scholar

Viswanathan Vijayan, University of Madras

Center for Advanced Studies in Crystallography and Biophysics

Research Scholar

Barij Nayan Sinha, Birla Institute of Technology

Department of Pharmaceutical Sciences & Technology


Velmurugan Devadasan, University of Madras

Center for Advanced Studies in Crystallography and Biophysics



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