Medicinal and pharmaceutical chemistry
Journal of Pharmaceutical Chemistry(JPC)
An online, open-access, peer-reviewed journal publishing research across the full spectrum of drug discovery and development, with an emphasis on the relationship between chemical structure and biological activity.
- eISSN
- 2349-5731
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All 192 articlesResearch Articles
Vol. 9 (2023)
Molecular Docking Studies of Novel Thiazolidinedionederivatives as PPARγ Modulators
Deepak Shilkar, Sabina Yasmin
Thiazolidinediones (TZDs), a well-known target of peroxisome proliferated receptors (PPARγ), have been clinically used as antidiabetic agents. PPARs belong to the nuclear receptor superfamily and are important targets…
2023-12-14pp. 12-21doi:10.14805/jphchem.2023.art124
Research Articles
Vol. 9 (2023)
Synthesis, crystal structure, and Hirschfeld surface analysis of novel ethyl 5-bromo-2-(4-methoxyphenyl) oxazole-4-carboxylate
Sheikh Murtuja, Venkatesan Jayaprakash, Barij Nayan Sinha
A new oxazole derivative, ethyl 5-bromo-2-(4-methoxyphenyl) oxazole-4-carboxylate, was synthesized and characterized by IR spectroscopy, 13C NMR, Mass spectroscopy, and single-crystal X-ray diffraction analysis. The…
2023-07-11doi:10.14805/jphchem.2023.art297
Conference Abstract
Vol. 8 No. Supplement (2022)
#113: Identification of newer hits as potential FAK inhibitors using in-silico methods
Sahaya Nadar, Tabassum Khan
Focal adhesion kinase (FAK), a protein tyrosine kinase has been found to be overexpressed in cancer cells and plays a pivotal role in the proliferation of tumour malignancy. By far, there is no FDA approved and marketed…
2022-07-20
Conference Abstract
Vol. 8 No. Supplement (2022)
#1 NSAIDs’ antimicrobial mechanisms of action by inhibiting drug efflux and biofilm formation
Sanjib Bhakta
The rise of antimicrobial drug resistance (AMR) in tuberculosis (TB) and non-tubercular mycobacte-rial (NTM) infection coupled with the shortage of new antibiotics has elevated the global infectiousdisease to a major…
2022-07-20
Conference Abstract
Vol. 8 No. Supplement (2022)
#2 Extraction of Naturally Occuring Cannabinoids : Recent Advances
Satyajit Sarker
Cannabinoids are the compounds that bind to cannabinoid receptors (endocannabinoid system), and they are one of the most investigated groups of natural products. Cannabis sativa L. (family:Cannabaceae), an herbaceous…
2022-07-20
Conference Abstract
Vol. 8 No. Supplement (2022)
#3 Assessment of drug-drug interaction in pediatric drug development: Application of physiology-based pharmacokinetic modeling
Jaydeep Sinha
Assessment of pharmacokinetic (PK) drug-drug interaction (DDI) is an important requirement of drug development. This is necessary because characterizing the clinically relevant DDIs inform the dose adjustment strategy…
2022-07-20